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How Taken: Use Methotrexate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Methotrexate by mouth with or without food. However, you should take it the same way each time in relation to food.
Drinking extra fluids while you are taking Methotrexate is recommended. Check with your doctor for instructions.
Be sure you understand exactly how much of Methotrexate to take and how often you should take it. Ask your doctor or pharmacist if you have any questions.
It may take several weeks for your symptoms to improve. Do not stop taking Methotrexate without checking with your doctor.
Methotrexate works best if each dose is taken at the scheduled time.
Continue to take Methotrexate even if you feel well. Do not miss any doses.

Drug Class and Mechanism: Methotrexate is an antimetabolite. It works to treat cancer and psoriasis by blocking an enzyme needed for cell growth. This helps to slow the growth of cancer cells and abnormal skin cells. Exactly how Methotrexate works to treat rheumatoid arthritis is unknown. It reduces symptoms of inflammation (e.g., pain, swelling, stiffness) caused by rheumatoid arthritis.

Missed Dose: If you miss a dose of Methotrexate, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Warnings Precautions: Do not use Methotrexate if:

you are allergic to any ingredient in Methotrexate;
you are treating psoriasis or rheumatoid arthritis and you are pregnant or breast-feeding;
you are treating psoriasis or rheumatoid arthritis and abuse alcohol or have liver problems, an immunodeficiency syndrome (e.g., AIDS), bone marrow problems, or blood problems (e.g., anemia, low white blood cell count, low platelet count);
you have moderate or severe kidney problems;
you are taking acitretin.

Contact your doctor or health care provider right away if any of these apply to you.

Important:

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